anti-CASC5 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CASC5
  • 反应物种: Hu, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CASC5
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-300 of Human CASC5 (NP_733468.3).
  • Brand:
CAT.NO. : ARG40018
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CASC5
反应物种Hu, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CASC5
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-300 of Human CASC5 (NP_733468.3).
偶联标记Un-conjugated
別名PPP1R55; D40; Cancer/testis antigen 29; AF15q14; hSpc105; Blinkin; Protein CASC5; Bub-linking kinetochore protein; CT29; hKNL-1; KNL1; Kinetochore-null protein 1; Protein D40/AF15q14; Spc7; AF15Q14; ALL1-fused gene from chromosome 15q14 protein; Cancer susceptibility candidate gene 5 protein
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:100
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Jurkat
实际分子量300 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 57082 Human CASC5

Swiss-port # Q8NG31 Human Protein CASC5

基因名称CASC5
全名cancer susceptibility candidate 5
背景介绍The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
生物功能Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. [UniProt]
细胞定位Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle. [UniProt]
预测分子量265 kDa
检测图片 (3)
  • ARG40018 anti-CASC5 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat testis stained with ARG40018 anti-CASC5 antibody at 1:100 dilution.

  • ARG40018 anti-CASC5 antibody WB image

    Western blot: 25 µg of Jurkat cell lysate stained with ARG40018 anti-CASC5 antibody at 1:1000 dilution.

  • ARG40018 anti-CASC5 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human colon stained with ARG40018 anti-CASC5 antibody at 1:100 dilution.

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