anti-Caspase 4 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Caspase 4
  • 反应物种: Hu, Ms, Rat
  • 预测物种: Bov
  • 应用: ELISA, IHC, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Caspase 4
  • 抗原物种: Bovine
  • Brand:
CAT.NO. : ARG55178
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Caspase 4
反应物种Hu, Ms, Rat
预测物种Bov
应用ELISA, IHC, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Caspase 4
抗原物种Bovine
抗原Synthetic peptide (15 aa) within aa. 80-130 of Bovine Caspase-13.
偶联标记Un-conjugated
別名Mih1/TX; Protease ICH-2; Caspase-4; EC 3.4.22.57; TX; CASP-4; Protease TX; ICE; ICH-2; ICE(rel)II; rel; ICEREL-II
应用说明
应用建议
应用推荐稀释比
ELISAAssay-dependent
IHC10 μg/ml
WB1 μg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HL60 Cell Lysate
属性
形式Liquid
纯化Ion exchange chromatography purified.
缓冲液PBS and 0.02% Sodium azide
抗菌剂0.02% Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 12363 Mouse CASP4

GeneID: 837 Human CASP4

Swiss-port # P49662 Human Caspase-4

Swiss-port # P70343 Mouse Caspase-4

基因名称CASP4
全名caspase 4, apoptosis-related cysteine peptidase
背景介绍Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13. Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.
生物功能Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. [UniProt]
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody
预测分子量43 kDa
翻译后修饰In response to activation signals, including endoplasmic reticulum stress or treatment with amyloid beta A4 protein fragments (such as beta-amyloid protein 40), undergoes autoproteolytic cleavage.
检测图片 (2)
  • ARG55178 anti-Caspase 4 antibody WB image

    Western blot: Human HL60 cell lysate (A), Mouse brain (B) and Rat brain (C) tissue lysates stained with ARG55178 anti-Caspase 4 antibody at 1 ug/ml dilution.

  • ARG55178 anti-Caspase 4 antibody IHC image

    Immunohistochemistry: caspase-13 in Mouse brain tissue stained with ARG55178 anti-Caspase 4 antibody at 10 ug/ml dilution.

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