anti-Caspase 7 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55181
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Caspase 7 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, IHC-P, WB |
| 特异性 | Depending on cell lines or tissues used, other cleavage products may be observed. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Caspase 7 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (16 aa) within the last 50 aa of Human Caspase-7. |
| 偶联标记 | Un-conjugated |
| 別名 | ICE-LAP3; Caspase-7; CASP-7; LICE2; ICE-like apoptotic protease 3; Apoptotic protease Mch-3; EC 3.4.22.60; CMH-1; MCH3 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Human Skeletal Muscle Tissue Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASP7 |
| 全名 | caspase 7, apoptosis-related cysteine peptidase |
| 背景介绍 | Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. |
| 生物功能 | Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. |
检测图片 (2)
ARG55181 anti-Caspase 7 antibody WB image
Western blot: 20 µg of 293T cell lysate stained with ARG55181 anti-Caspase 7 antibody at 1:1000 diltion.
ARG55181 anti-Caspase 7 antibody IHC image
Immunohistochemistry: Human skeletal muscle stained with ARG55181 anti-Caspase 7 antibody at 2 ug/ml dilution.
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