anti-CBX3 / HP1 gamma antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
-
Brand:
CAT.NO. : ARG59773
US＄ Please choose
US＄ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CBX3 / HP1 gamma |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CBX3 / HP1 gamma |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-183 of Human CBX3 (NP_009207.2). |
| 偶联标记 | Un-conjugated |
| 別名 | HP1-GAMMA; Chromobox protein homolog 3; HP1Hs-gamma; HP1 gamma; HECH; Heterochromatin protein 1 homolog gamma; Modifier 2 protein |
应用说明
| 应用建议 |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | Mouse lung and 293T | ||||||||||
| 实际分子量 | 23 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CBX3 |
| 全名 | chromobox homolog 3 |
| 背景介绍 | At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011] |
| 生物功能 | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. [UniProt] |
| 细胞定位 | Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). [UniProt] |
| 产品亮点 | Related products: CBX3 antibodies; CBX3 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Senescence Marker Antibody Panel is launched |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. [UniProt] |
检测图片 (4)
ARG59773 anti-CBX3 / HP1 gamma antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG59773 anti-CBX3 / HP1 gamma antibody at 1:100 dilution.
ARG59773 anti-CBX3 / HP1 gamma antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer stained with ARG59773 anti-CBX3 / HP1 gamma antibody at 1:200 dilution.
ARG59773 anti-CBX3 / HP1 gamma antibody WB image
Western blot: 25 µg of Mouse lung and 293T cell lysates stained with ARG59773 anti-CBX3 / HP1 gamma antibody at 1:1000 dilution through one-step method.
ARG59773 anti-CBX3 / HP1 gamma antibody WB image
Western blot: Extracts from normal (control) and CBX3 knockout (KO) HeLa cells, using ARG59773 anti-CBX3 / HP1 gamma antibody at 1:500 dilution.
New Products
