anti-CCM2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG64074
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes CCM2 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms, Cow, Dog |
| 应用 | FACS, ICC/IF, WB |
| 特异性 | This antibody is expected to recognize isoform 1 (NP_001025006.1), isoform 2 (NP_113631.1) and isoform 4 (NP_001161407.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CCM2 |
| 抗原物种 | Human |
| 抗原 | C-KGEKSRDKKAHEK |
| 偶联标记 | Un-conjugated |
| 別名 | PP10187; Cerebral cavernous malformations 2 protein; Malcavernin; OSM; C7orf22 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9BSQ5 Human Cerebral cavernous malformations 2 protein |
|---|---|
| 背景介绍 | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
| 研究领域 | Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 49 kDa |
检测图片 (3)
ARG64074 anti-CCM2 antibody IHC-P image
Immunohistochemistry: U2OS stained with ARG64074anti-CCM2 antibody at 10ug/ml dilution.
ARG64074 anti-CCM2 antibody WB image
Western Blot: Human Heart lysate (35 µg protein in RIPA buffer) stained with ARG64074 anti-CCM2 antibody at 1 µg/ml dilution.
ARG64074 anti-CCM2 antibody FACS image
Flow Cytometry: KNRK stained with ARG64074anti-CCM2 antibody at 10ug/ml dilution.
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