anti-CCP110 / Cep110 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CCP110 / Cep110
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CCP110 / Cep110
  • 抗原物种: Human
  • 抗原: Recombinant protein corresponding to E51-H284 of Human CCP110 / Cep110.
  • Brand:
CAT.NO. : ARG59202
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CCP110 / Cep110
反应物种Hu, Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CCP110 / Cep110
抗原物种Human
抗原Recombinant protein corresponding to E51-H284 of Human CCP110 / Cep110.
偶联标记Un-conjugated
別名CP110; Centriolar coiled-coil protein of 110 kDa; Cep110; Centrosomal protein of 110 kDa
应用说明
应用建议
应用推荐稀释比
IHC-P0.5 - 1 µg/ml
WB0.1 - 0.5 µg/ml
应用说明IHC-P: Antigen Retrieval: Heat mediated was performed in Citrate buffer (pH 6.0) for 20 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose.
抗菌剂0.05% Sodium azide
稳定剂4% Trehalose
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 101565 Mouse CCP110

GeneID: 9738 Human CCP110

Swiss-port # O43303 Human Centriolar coiled-coil protein of 110 kDa

Swiss-port # Q7TSH4 Mouse Centriolar coiled-coil protein of 110 kDa

基因名称CCP110
全名centriolar coiled coil protein 110kDa
生物功能Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. [UniProt]
细胞定位Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. [UniProt]
预测分子量113 kDa
翻译后修饰Phosphorylated by CDKs.

Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. [UniProt]
检测图片 (3)
  • ARG59202 anti-CCP110 / Cep110 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse testis tissue. Antigen Retrieval: Heat mediated was performed in Citrate buffer (pH 6.0, epitope retrieval solution) for 20 min. The tissue section was blocked with 10% goat serum. The tissue section was then stained with ARG59202 anti-CCP110 / Cep110 antibody at 1 µg/ml dilution, overnight at 4°C.

  • ARG59202 anti-CCP110 / Cep110 antibody WB image

    Western blot: 50 µg of samples under reducing conditions. HeLa, Rat testis, Mouse testis, Mouse spleen and Mouse thymus lysates stained with ARG59202 anti-CCP110 / Cep110 antibody at 0.5 µg/ml, overnight at 4°C.

  • ARG59202 anti-CCP110 / Cep110 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat testis tissue. Antigen Retrieval: Heat mediated was performed in Citrate buffer (pH 6.0, epitope retrieval solution) for 20 min. The tissue section was blocked with 10% goat serum. The tissue section was then stained with ARG59202 anti-CCP110 / Cep110 antibody at 1 µg/ml dilution, overnight at 4°C.

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