anti-CD101 antibody [BB27] (FITC)
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Key features and details
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- 反应物种:
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- 克隆:
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- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG23531
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Product Details
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [BB27] recognizes CD101. Mouse anti Human CD101 antibody, clone BB27 recognizes human CD101. CD101 is a ~140 kDa homodimeric cell surface glycoprotein expressed primarily by monocytes, granulocytes, dendritic cells and activated T lymphocytes. CD101 plays a major role in the activation of T cells by skin dendritic cells. Mouse anti Human CD101 antibody, clone BB27 has been reported to inhibit allogeneic T-cell responses (Bagot et al. 1997). |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BB27 |
| 同位型 | IgG1 |
| 靶点名称 | CD101 |
| 抗原物种 | Human |
| 抗原 | Human thymic clone B12. |
| 偶联标记 | FITC |
| 別名 | Immunoglobulin superfamily member 2; IgSF2; CD antigen CD101; Cell surface glycoprotein V7; EWI-101; IGSF2; V7; Glu-Trp-Ile EWI motif-containing protein 101 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS, 0.09% Sodium azide and 1% BSA. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 1% BSA |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q93033 Human Immunoglobulin superfamily member 2 |
|---|---|
| 基因名称 | CD101 |
| 全名 | CD101 molecule |
| 生物功能 | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. [UniProt] |
| 预测分子量 | 115 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
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