anti-CD105 / Endoglin antibody [MJ7/18] (PE)
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Key features and details
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- 靶点名称:
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CAT.NO. : ARG65508
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Product Details
概述
| 产品描述 | PE-conjugated Rat Monoclonal antibody [MJ7/18] recognizes CD105 / Endoglin |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS |
| 特异性 | The clone MJ7/18 reacts with CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | MJ7/18 |
| 同位型 | IgG2a |
| 靶点名称 | CD105 / Endoglin |
| 抗原物种 | Mouse |
| 抗原 | Inflamed mouse skin |
| 偶联标记 | PE |
| 別名 | CD antigen CD105; HHT1; Endoglin; ORW1; END |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.5 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Eng |
| 全名 | endoglin |
| 背景介绍 | CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| 生物功能 | Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 71 kDa |
检测图片 (1)
ARG65508 anti-CD105 / Endoglin antibody [MJ7/18] (PE) FACS image
Flow Cytometry: Murine bone marrow stained with ARG65508 anti-CD105 / Endoglin antibody [MJ7/18] (PE).
参考文献
克隆号文献
Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro.
FACS / Mouse
A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.
WB /
Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.
IHC-Fr /
Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.
IHC-Fr /
Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.
WB, IHC-Fr /
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