anti-CD107a / LAMP1 antibody [H4A3] (PE)
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Key features and details
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [H4A3] recognizes CD107a / LAMP1 |
|---|---|
| 反应物种 | Hu, Ms, NHuPrm |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody H4A3 recognizes LAMP1 / CD107a, an approximately 100120 kDa glycoprotein expressed mainly on lysosomal, but also on the plasma membrane. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | H4A3 |
| 同位型 | IgG1 |
| 靶点名称 | CD107a / LAMP1 |
| 抗原物种 | Human |
| 抗原 | Human PBMC |
| 偶联标记 | PE |
| 別名 | LGP120; CD107a; LAMPA; CD antigen CD107a; Lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; LAMP-1; Lysosome-associated membrane protein 1 |
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 0.02% Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P11279 Human Lysosome-associated membrane glycoprotein 1 Swiss-port # P11438 Mouse Lysosome-associated membrane glycoprotein 1 |
|---|---|
| 基因名称 | LAMP1 |
| 全名 | lysosomal-associated membrane protein 1 |
| 背景介绍 | CD107a (lysosome-associated membrane protein-1, LAMP-1), together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. Increased CD107a immunoreactivity is observed in neurones, and in glial cells surrounding senile plaques in Alzheimers disease cases and is localized mainly in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. CD107a is a good marker of mast cell activation. |
| 生物功能 | Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. [UniProt] |
| 研究领域 | Cancer antibody; Cell Death antibody; Controls and Markers antibody; Developmental Biology antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody; Lysosome Marker antibody |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells. |
ARG54251 anti-CD107a / LAMP1 antibody [H4A3] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG54251 anti-CD107a / LAMP1 antibody [H4A3] (PE).
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