anti-CD152 / CTLA4 antibody [1B8] (PE)

CAT.NO. : ARG21004

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Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	PE-conjugated Hamster Monoclonal antibody [1B8] recognizes CD152 / CTLA4
反应物种	Ms
应用	FACS, FLISA
特异性	Mouse CD152.
宿主	Hamster
克隆	Monoclonal
克隆号	1B8
同位型	IgG1
靶点名称	CD152 / CTLA4
抗原物种	Mouse
抗原	Extracellular portion of murine CTLA-4 fused to a murine IgG2a
偶联标记	PE
別名	GRD4; CTLA-4; CELIAC3; CD; Cytotoxic T-lymphocyte-associated antigen 4; CD152; GSE; CD antigen CD152; Cytotoxic T-lymphocyte protein 4; ALPS5; IDDM12

应用说明

应用建议

应用	推荐稀释比
FACS
FLISA

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
缓冲液	PBS, 0.1% Sodium azide and Sucrose.
抗菌剂	0.1% Sodium azide
稳定剂	Sucrose
浓度	0.1 mg/ml
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12477 Mouse CTLA4 Swiss-port # P09793 Mouse Cytotoxic T-lymphocyte protein 4
基因名称	CTLA4
全名	cytotoxic T-lymphocyte-associated protein 4
背景介绍	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
生物功能	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [UniProt]
预测分子量	25 kDa
翻译后修饰	N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.

检测图片 (1)

ARG21004 anti-CD152 / CTLA4 antibody [1B8] (PE) FLISA image
FLISA: The plate was coated with Mouse CD152 / CTLA4 and purified/unlabeled Rat IgG1κ. CTLA4 and purified immunoglobulin were detected with serially diluted ARG21004 anti-CD152 / CTLA4 antibody [1B8] (PE).

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