anti-CD152 / CTLA4 antibody [1E6]

CAT.NO. : ARG58439

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Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal [1E6] antibody recognizes CD152 / CTLA4
反应物种	Hu
应用	ICC/IF, IHC-P, WB
宿主	Mouse
克隆	Monoclonal
克隆号	1E6
同位型	IgG1
靶点名称	CD152 / CTLA4
抗原物种	Human
抗原	Synthetic peptide around the extracellular domain of Human CD152 / CTLA4.
偶联标记	Un-conjugated
別名	GRD4; CTLA-4; CELIAC3; CD; Cytotoxic T-lymphocyte-associated antigen 4; CD152; GSE; CD antigen CD152; Cytotoxic T-lymphocyte protein 4; ALPS5; IDDM12

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

HEK293

实际分子量

32 kDa

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS and 0.02% Sodium azide.
抗菌剂	0.02% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1493 Human CTLA4 Swiss-port # P16410 Human Cytotoxic T-lymphocyte protein 4
基因名称	CTLA4
全名	cytotoxic T-lymphocyte-associated protein 4
背景介绍	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
生物功能	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [UniProt]
预测分子量	25 kDa
翻译后修饰	N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. [UniProt]

检测图片 (7)

ARG58439 anti-CD152 / CTLA4 antibody [1E6] IF image
Immunofluorescence: CTLA4 transfected HEK293 cells stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 20 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] IHC image
Immunohistochemistry: Human lymph node tissue stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 20 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] WB image
Western blot: CTLA4 overexpressing HEK293 cell lysate stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 0.125 and 0.25 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] ICC image
Immunocytochemistry: CTLA4 transfected HEK293 cells stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 5 µg/ml dilution. Lower left (control): Mouse IgG antibody at 5 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] IHC image
Immunohistochemistry: Human tonsil tissue stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 20 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] IHC-P image
Immunohistochemistry: Human lymph node tissue stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 5 µg/ml dilution.
ARG58439 anti-CD152 / CTLA4 antibody [1E6] IHC-P image
Immunohistochemistry: Human tonsil tissue stained with ARG58439 anti-CD152 / CTLA4 antibody [1E6] at 5 µg/ml dilution.