anti-CD152 / CTLA4 antibody [9H10]

CAT.NO. : ARG22065

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Size:

100 μg 50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Syrian Hamster Monoclonal antibody [9H10] recognizes CD152 / CTLA4
反应物种	Ms
应用	BL, ELISA, FACS, IP
特异性	Mouse CD152
宿主	Hamster
克隆	Monoclonal
克隆号	9H10
同位型	IgG2
靶点名称	CD152 / CTLA4
抗原物种	Mouse
抗原	Heat-killed Staphylococcus A bacteria coated with Mouse CTLA-4/Human IgG1 fusion protein
偶联标记	Un-conjugated
別名	GRD4; CTLA-4; CELIAC3; CD; Cytotoxic T-lymphocyte-associated antigen 4; CD152; GSE; CD antigen CD152; Cytotoxic T-lymphocyte protein 4; ALPS5; IDDM12

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
缓冲液	BBS (pH 8.2)
浓度	0.5 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12477 Mouse CTLA4 Swiss-port # P09793 Mouse Cytotoxic T-lymphocyte protein 4
基因名称	CTLA4
全名	cytotoxic T-lymphocyte-associated protein 4
背景介绍	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
生物功能	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. [UniProt]
预测分子量	25 kDa
翻译后修饰	N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.

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