anti-CD158f / KIR2DL5 antibody [UP-R1] (APC)
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Key features and details
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CAT.NO. : ARG42305
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [UP-R1] recognizes CD158f / KIR2DL5 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody UP-R1 recognizes an extracellular epitope on CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | UP-R1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD158f / KIR2DL5 |
| 抗原物种 | Human |
| 抗原 | Human CD158f-Ig fusion protein. |
| 偶联标记 | APC |
| 別名 | CD antigen CD158f1; KIR2DL5.3; KIR2DL5.1; Killer cell immunoglobulin-like receptor 2DL5A; KIR2DL5; CD158F |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q8N109 Human Killer cell immunoglobulin-like receptor 2DL5A |
|---|---|
| 基因名称 | KIR2DL5A |
| 全名 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A |
| 背景介绍 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 41 kDa |
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