anti-CD170 / Siglec 5 antibody [1A5]

产品描述: Mouse Monoclonal antibody [1A5] recognizes CD170 / Siglec 5
反应物种: Hu, NHuPrm
应用: ELISA, FACS, ICC/IF, IHC-Fr, IP
特异性: The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
宿主: Mouse
克隆: Monoclonal
克隆号: 1A5
同位型: IgG1
靶点名称: CD170 / Siglec 5

CAT.NO. : ARG42427

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Size:

100 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [1A5] recognizes CD170 / Siglec 5
反应物种	Hu, NHuPrm
应用	ELISA, FACS, ICC/IF, IHC-Fr, IP
特异性	The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
宿主	Mouse
克隆	Monoclonal
克隆号	1A5
同位型	IgG1
靶点名称	CD170 / Siglec 5
抗原物种	Human
抗原	Fusion protein composed of Human CD170 extracellular domain and Fc region of Human IgG1.
偶联标记	Un-conjugated
別名	OBBP2; OB-binding protein 2; CD170; Sialic acid-binding Ig-like lectin 5; SIGLEC-5; CD antigen CD170; CD33 antigen-like 2; OB-BP2; CD33L2; Siglec-5; Obesity-binding protein 2

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8778 Human SIGLEC5 Swiss-port # O15389 Human Sialic acid-binding Ig-like lectin 5
基因名称	SIGLEC5
全名	sialic acid binding Ig-like lectin 5
背景介绍	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
生物功能	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. [UniProt]
细胞定位	Membrane; Single-pass type I membrane protein. [UniProt]
预测分子量	61 kDa

检测图片 (1)

ARG42427 anti-CD170 / Siglec 5 antibody [1A5] FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42427 anti-CD170 / Siglec 5 antibody [1A5], followed by APC-conjugated Goat anti-Mouse antibody.

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