anti-CD172a / SIRP alpha antibody [15-414] (APC)
![anti-CD172a / SIRP alpha antibody [15-414] (APC)](/upload/image/products/ARG44056_210_205.jpg)
![anti-CD172a / SIRP alpha antibody [15-414] (APC)](/upload/image/products/ARG44056.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG44056
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody recognizes CD172a / SIRP alpha. |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 15-414 |
| 同位型 | IgG2a |
| 靶点名称 | CD172a / SIRP alpha |
| 抗原物种 | Human |
| 抗原 | Human CD172a / SIRP alpha fusion protein. |
| 偶联标记 | APC |
| Protein Full name | Tyrosine-protein phosphatase non-receptor type substrate 1 |
| 別名 | SIRPA; Signal Regulatory Protein Alpha; SHPS1; SIRP; BIT; P84; MFR; SHPS-1; PTPNS1; MYD-1; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; CD172 Antigen-Like Family Member A; Inhibitory Receptor SHPS-1; Macrophage Fusion Receptor; SIRP-ALPHA-1; SIRPalpha2; SIRPalpha; CD172a; Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs; Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs; Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1; Tyrosine Phosphatase SHP Substrate 1; Signal-Regulatory Protein Alpha-1; Signal-Regulatory Protein Alpha-2; Signal-Regulatory Protein Alpha-3; Signal-Regulatory Protein Alpha; SHP Substrate 1; CD172a Antigen; Myd-1 Antigen; MyD-1 Antigen; Sirp-Alpha-1; Sirp-Alpha-2; Sirp-Alpha-3; CD172A; MYD1; Bit |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | The purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P78324 Human Tyrosine-protein phosphatase non-receptor type substrate 1 |
|---|---|
| 基因名称 | SIRPA |
| 全名 | Signal Regulatory Protein Alpha |
| 背景介绍 | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. |
| 生物功能 | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. |
| 细胞定位 | Membrane |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein |
检测图片 (1)
ARG44056 anti-CD172a / SIRP alpha antibody [15-414] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44056 anti-CD172a / SIRP alpha antibody [15-414] (APC) at 10 μl / 10^6 cells dilution.
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