anti-CD193 / CCR3 antibody [5E8]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [5E8] recognizes CD193 / CCR3
  • 反应物种: Hu
  • 应用: FACS
  • 特异性: The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: 5E8
  • 同位型: IgG2b, kappa
  • 靶点名称: CD193 / CCR3
  • Brand:
CAT.NO. : ARG42435
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Product Details
概述
产品描述Mouse Monoclonal antibody [5E8] recognizes CD193 / CCR3
反应物种Hu
应用FACS
特异性The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
宿主Mouse
克隆Monoclonal
克隆号5E8
同位型IgG2b, kappa
靶点名称CD193 / CCR3
抗原物种Human
抗原Human CD193 / CCR3.
偶联标记Un-conjugated
別名C-C chemokine receptor type 3; CD193; CKR3; CCR-3; Eosinophil eotaxin receptor; CMKBR3; C-C CKR-3; CCR3; CC-CKR-3; CD antigen CD193
应用说明
应用建议
应用推荐稀释比
FACS1 - 4 µg/ml
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS and 15 mM Sodium azide.
抗菌剂15 mM Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1232 Human CCR3

Swiss-port # P51677 Human C-C chemokine receptor type 3

基因名称CCR3
全名chemokine (C-C motif) receptor 3
背景介绍The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
生物功能Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. [UniProt]
细胞定位Cell membrane; Multi-pass membrane protein. [UniProt]
预测分子量41 kDa
检测图片 (1)
  • ARG42435 anti-CD193 / CCR3 antibody [5E8] FACS image

    Flow Cytometry: Human peripheral blood stained with ARG42435 anti-CD193 / CCR3 antibody [5E8], followed by APC-conjugated Goat anti-Mouse antibody.

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