anti-CD1b antibody [SN13] (FITC)
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CAT.NO. : ARG65538
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Product Details
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [SN13] recognizes CD1b |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone SN13 (also known as K5-1B8) recognizes CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SN13 |
| 同位型 | IgG1 |
| 靶点名称 | CD1b |
| 抗原物种 | Human |
| 抗原 | A cell membrane antigen preparation that was isolated from normal human thymocytes |
| 偶联标记 | FITC |
| 別名 | T-cell surface glycoprotein CD1b; CD1A; R1; CD antigen CD1b; CD1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD1B |
| 全名 | CD1b molecule |
| 背景介绍 | CD1b (also known as R1) together with CD1a and c, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve asantigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. Besides non-peptide glycolipid antigen presentation to CD1-restricted T cells, CD1b has been implicated in thymocyte development. |
| 生物功能 | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 37 kDa |
检测图片 (1)
ARG65538 anti-CD1b antibody [SN13] (FITC) FACS image
Flow Cytometry: Separation of human CD1b positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) from CD1b negative monocytes (blue). Stimulated (GM-CSF + IL-4) human peripheral blood mononuclear cells stained with ARG65538 anti-CD1b antibody [SN13] (FITC) (4 µl reagent / 10^6 cells in 100 µl of cell suspension).
参考文献
克隆号文献
Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice.
WB / Human
Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells.
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