anti-CD206 / MMR antibody [15-2] (FITC)

产品描述: FITC-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR
反应物种: Hu
应用: FACS
特异性: The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
宿主: Mouse
克隆: Monoclonal
克隆号: 15-2
同位型: IgG1, kappa
靶点名称: CD206 / MMR

CAT.NO. : ARG42334

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Size:

50 tests

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Product Details

概述

产品描述	FITC-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR
反应物种	Hu
应用	FACS
特异性	The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes.
宿主	Mouse
克隆	Monoclonal
克隆号	15-2
同位型	IgG1, kappa
靶点名称	CD206 / MMR
抗原物种	Human
抗原	Purified Human MMR.
偶联标记	FITC
別名	CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

应用说明

应用建议

应用	推荐稀释比
FACS	4 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 4360 Human MRC1 Swiss-port # P22897 Human Macrophage mannose receptor 1
基因名称	MRC1
全名	mannose receptor, C type 1
背景介绍	The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
生物功能	Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
细胞定位	Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. [UniProt]
产品亮点	Related products: CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH
预测分子量	166 kDa

检测图片 (3)

ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Human stimulated monocytes (GM-CSF + IL-4) stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 10^6 cells in 100 µl of cell suspension.
ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Human stimulated monocytes (GM-CSF + IL-4) stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 10^6 cells in 100 µl of cell suspension and ARG53761 anti-CD11c antibody [BU15] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Separation of Human CD206 positive CD11c positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed). Cells were stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 100 µl of peripheral whole blood.

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