anti-CD206 / MMR antibody [15-2] (PE)
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Product Details
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS |
| 特异性 | This antibody recognizes CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 15-2 |
| 同位型 | IgG1 |
| 靶点名称 | CD206 / MMR |
| 抗原物种 | Human |
| 抗原 | Purified Human CD206 / MMR (NP_002429.1). |
| 偶联标记 | PE |
| 別名 | CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1 |
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
|---|---|
| 基因名称 | MRC1 |
| 全名 | mannose receptor, C type 1 |
| 背景介绍 | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015] |
| 生物功能 | CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt] |
| 产品亮点 | Related products: CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH |
| 研究领域 | Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody |
| 预测分子量 | 166 kDa |
ARG55633 anti-CD206 / MMR antibody [15-2] (PE) FACS image
Flow Cytometry: Stimulated (GM-CSF + IL-4) human peripheral blood mononuclear cells stained with ARG55633 anti-CD206 / MMR antibody [15-2] (PE) (10 µl reagent / 10^6 cells in 100 µl of cell suspension).
ARG55633 anti-CD206 / MMR antibody [15-2] (PE) FACS image
Flow Cytometry: Stimulated (GM-CSF + IL-4) human peripheral blood mononuclear cells stained with ARG55633 anti-CD206 / MMR antibody [15-2] (PE) (10 µl reagent / 10^6 cells in 100 µl of cell suspension) and ARG53761 anti-CD11c antibody [BU15] (APC) (10 µl reagent / 10^6 cells in 100 µl of cell suspension).
ARG55633 anti-CD206 / MMR antibody [15-2] (PE) FACS image
Flow Cytometry: Separation of human CD206 positive CD11c positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed). Human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained with ARG55633 anti-CD206 / MMR antibody [15-2] (PE) (10 µl reagent / 100 µl of peripheral whole blood).
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