anti-CD206 / MMR antibody [MR5D3]

Key features and details

产品描述: Rat Monoclonal antibody [MR5D3] recognizes CD206 / MMRThis antibody recognizes the mouse mannose receptor, a 175kD type 1 membrane glycoprotein that is also known as CD206. CD206 is expressed on most tissue macrophages, certain endothelial cells, and in vitro derived dendritic cells.
反应物种: Ms
应用: FACS, ICC/IF, IHC-Fr, IHC-P, IP
宿主: Rat
克隆: Monoclonal
克隆号: MR5D3
同位型: IgG2a
靶点名称: CD206 / MMR
抗原物种: Mouse

Brand:

CAT.NO. : ARG22456

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Size:

100 μg

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*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rat Monoclonal antibody [MR5D3] recognizes CD206 / MMR This antibody recognizes the mouse mannose receptor, a 175kD type 1 membrane glycoprotein that is also known as CD206. CD206 is expressed on most tissue macrophages, certain endothelial cells, and in vitro derived dendritic cells.
反应物种	Ms
应用	FACS, ICC/IF, IHC-Fr, IHC-P, IP
宿主	Rat
克隆	Monoclonal
克隆号	MR5D3
同位型	IgG2a
靶点名称	CD206 / MMR
抗原物种	Mouse
抗原	Chimaeric CRD4-7-Fc protein
偶联标记	Un-conjugated
別名	CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1

应用说明

应用建议

应用	推荐稀释比
FACS	1:10 - 1:20
ICC/IF	Assay-dependent
IHC-Fr	Assay-dependent
IHC-P	Assay-dependent
IP	Assay-dependent

应用说明

FACS: CD206 is expressed weakly at the cell surface. Staining may be increased following membrane permeabilisation. Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS and 0.09% Sodium azide
抗菌剂	0.09% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 17533 Mouse MRC1 Swiss-port # Q61830 Mouse Macrophage mannose receptor 1
基因名称	Mrc1
全名	mannose receptor, C type 1
背景介绍	The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015]
生物功能	CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt]
产品亮点	Related products: CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Rat IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH
研究领域	Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
预测分子量	166 kDa

检测图片 (7)

ARG22456 anti-CD206 / MMR antibody [MR5D3] ICC/IF image
Immunofluorescence: Mouse macrophagesstained with ARG22456 anti-CD206 / MMR antibody [MR5D3] at 1:200 dilution.
From Qiu-Yue Lin et al. Clin Transl Med. (2021), doi: 10.1002/ctm2.374, Fig. S2.
ARG22456 anti-CD206 / MMR antibody [MR5D3] FACS image
Flow Cytometry: J774 cell line stained with ARG22456 anti-CD206 / MMR antibody [MR5D3] following permeabilization.
ARG22456 anti-CD206 / MMR antibody [MR5D3] IHC-Fr image
Immunohistochemistry: Mouse lymph node cryosection stained with ARG22456 anti-CD206 / MMR antibody [MR5D3]. (Low power).
ARG22456 anti-CD206 / MMR antibody [MR5D3] IHC-Fr image
Immunohistochemistry: Mouse lymph node cryosection stained with ARG22456 anti-CD206 / MMR antibody [MR5D3]. (Medium power).
ARG22456 anti-CD206 / MMR antibody [MR5D3] IHC-Fr image
Immunohistochemistry: Mouse lymph node cryosection stained with ARG22456 anti-CD206 / MMR antibody [MR5D3]. (High power).
ARG22456 anti-CD206 / MMR antibody [MR5D3] IHC-Fr image
Immunohistochemistry: Mouse lymph node cryosection stained with ARG22456 anti-CD206 / MMR antibody [MR5D3], green in A and Rat anti Mouse CD8 antibody, clone YTS105.18, red in B. C is the merged image with nuclei counterstained in blue using DAPI. (Low power).
ARG22456 anti-CD206 / MMR antibody [MR5D3] IHC-Fr image
Immunohistochemistry: Mouse lymph node cryosection stained with ARG22456 anti-CD206 / MMR antibody [MR5D3], green in A and Rat anti Mouse CD8 antibody, clone YTS105.18, red in B. C is the merged image with nuclei counterstained in blue using DAPI. (High power).