anti-CD223 / LAG3 antibody [C9B7W]

Key features and details

  • 产品描述: Rat Monoclonal antibody [C9B7W] recognizes CD223 / LAG3This antibody recognizes murine lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. Rat anti Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II (Workman et al. 2002).
  • 反应物种: Ms
  • 应用: CyTOF®-candidate, FACS
  • 宿主: Rat
  • 克隆: Monoclonal
  • 克隆号: C9B7W
  • 同位型: IgG1
  • 靶点名称: CD223 / LAG3
  • 抗原物种: Mouse
  • Brand:
CAT.NO. : ARG22550
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Product Details
概述
产品描述Rat Monoclonal antibody [C9B7W] recognizes CD223 / LAG3
This antibody recognizes murine lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. Rat anti Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II (Workman et al. 2002).
反应物种Ms
应用CyTOF®-candidate, FACS
宿主Rat
克隆Monoclonal
克隆号C9B7W
同位型IgG1
靶点名称CD223 / LAG3
抗原物种Mouse
抗原Murine CD223 Ig fusion protein.
偶联标记Un-conjugated
別名CD antigen CD223; CD223; Protein FDC; Lymphocyte activation gene 3 protein; LAG-3
应用说明
应用建议
应用推荐稀释比
CyTOF®-candidateAssay-dependent
FACSNeat - 1:5
应用说明FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% Sodium azide
抗菌剂0.09% Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 16768 Mouse LAG3

Swiss-port # Q61790 Mouse Lymphocyte activation gene 3 protein

基因名称Lag3
全名lymphocyte-activation gene 3
背景介绍Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
生物功能Involved in lymphocyte activation. Binds to HLA class-II antigens. [UniProt]
产品亮点Related products:
CD223 antibodies; Anti-Rat IgG secondary antibodies;
Related news:
CyTOF-candidate Antibodies
预测分子量57 kDa
检测图片 (1)
  • ARG22550 anti-CD223 / LAG3 antibody [C9B7W] FACS image

    Flow Cytometry: CD223 transfected cells stained with ARG22550 anti-CD223 / LAG3 antibody [C9B7W].

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