anti-CD230 / Prion protein antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes CD230 / Prion protein
  • 反应物种: Hu, Ms, Rat
  • 应用: FACS, ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: CD230 / Prion protein
  • 抗原物种: Human
  • 抗原: Synthetic peptide of Human CD230 / Prion protein.
  • Brand:
CAT.NO. : ARG41437
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes CD230 / Prion protein
反应物种Hu, Ms, Rat
应用FACS, ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称CD230 / Prion protein
抗原物种Human
抗原Synthetic peptide of Human CD230 / Prion protein.
偶联标记Un-conjugated
別名GSS; PrPc; PrP33-35C; PrP27-30; Alternative prion protein; p27-30; CJD; ASCR; CD230; PrP; PRIP; KURU; AltPrP
应用说明
应用建议
应用推荐稀释比
FACS1:50
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
WB1:1000 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Human fetal brain
实际分子量~ 28 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 19122 Mouse PRNP

GeneID: 24686 Rat PRNP

GeneID: 5621 Human PRNP

基因名称PRNP
全名prion protein
背景介绍The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
细胞定位Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. Isoform 2: Cytoplasm. Nucleus. Note=Accumulates outside the secretory route in the cytoplasm, from where it relocates to the nucleus. [UniProt]
预测分子量9 kDa
翻译后修饰The glycosylation pattern (the amount of mono-, di- and non-glycosylated forms or glycoforms) seems to differ in normal and CJD prion.

Isoform 2 is sumoylated with SUMO1. [UniProt]
检测图片 (1)
  • ARG41437 anti-CD230 / Prion protein antibody WB image

    Western blot: Human fetal brain lysate stained with ARG41437 anti-CD230 / Prion protein antibody.

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