anti-CD253 / TRAIL antibody [2E5] (PE)

产品描述: PE-conjugated Mouse Monoclonal antibody [2E5] recognizes CD253 / TRAIL
反应物种: Hu
不反应物种: Ms
应用: FACS
特异性: The clone 2E5 reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
宿主: Mouse
克隆: Monoclonal
克隆号: 2E5
同位型: IgG1

CAT.NO. : ARG54196

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Size:

50 μg

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Product Details

概述

产品描述	PE-conjugated Mouse Monoclonal antibody [2E5] recognizes CD253 / TRAIL
反应物种	Hu
不反应物种	Ms
应用	FACS
特异性	The clone 2E5 reacts with TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
宿主	Mouse
克隆	Monoclonal
克隆号	2E5
同位型	IgG1
靶点名称	CD253 / TRAIL
抗原物种	Human
抗原	Recombinant soluble fragment (aa 95-281) of human TRAIL.
偶联标记	PE
別名	TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10

应用说明

应用建议

应用	推荐稀释比
FACS	1 - 5 µg/ml

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化说明	The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
缓冲液	PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂	15 mM Sodium azide
稳定剂	0.2% (w/v) high-grade protease free BSA
浓度	0.1 mg/ml
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8743 Human TNFSF10 Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10
基因名称	TNFSF10
全名	tumor necrosis factor (ligand) superfamily, member 10
背景介绍	Human CD253 / TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).
生物功能	Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt]
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody
预测分子量	33 kDa
翻译后修饰	Tyrosine phosphorylated by PKDCC/VLK.