anti-CD253 / TRAIL antibody (Biotin)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Biotin-conjugated Rabbit Polyclonal antibody recognizes CD253 / TRAIL |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD253 / TRAIL |
| 抗原物种 | Mouse |
| 抗原 | E. coli derived recombinant Mouse CD253 / TRAIL. (MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN) |
| 偶联标记 | Biotin |
| 別名 | TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10 |
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by affinity chromatography. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P50592 Mouse Tumor necrosis factor ligand superfamily member 10 |
|---|---|
| 基因名称 | Tnfsf10 |
| 全名 | tumor necrosis factor (ligand) superfamily, member 10 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Tyrosine phosphorylated by PKDCC/VLK. |
ARG66149 anti-CD253 / TRAIL antibody (Biotin) WB image
Western blot: 250 - 0.24 ng of Mouse TRAIL stained with ARG66149 anti-CD253 / TRAIL antibody (Biotin), under non-reducing conditions.
ARG66149 anti-CD253 / TRAIL antibody (Biotin) standard curve image
Direct ELISA: ARG66149 anti-CD253 / TRAIL antibody (Biotin) at ~ 1.0 µg/ml results of a typical standard run with optical density reading at 405 - 650 nm.
ARG66149 anti-CD253 / TRAIL antibody (Biotin) WB image
Western blot: 250 - 0.24 ng of Mouse TRAIL stained with ARG66149 anti-CD253 / TRAIL antibody (Biotin), under reducing conditions.
ARG66149 anti-CD253 / TRAIL antibody (Biotin) standard curve image
Sandwich ELISA: ARG66149 anti-CD253 / TRAIL antibody (Biotin) as a detection antibody at 0.25 - 1.0 µg/ml combined with ARG66148 anti-CD253 / TRAIL antibody as a capture antibody. Results of a typical standard run with optical density reading at 405 - 650 nm.
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