anti-CD255 / TWEAK antibody [CARL-1] (low endotoxin)
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Key features and details
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CAT.NO. : ARG42384
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Product Details
概述
| 产品描述 | Azide free and low endotoxin Mouse Monoclonal antibody [CARL-1] recognizes CD255 / TWEAK |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, FuncSt, IHC |
| 特异性 | The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CARL-1 |
| 同位型 | IgG3, kappa |
| 靶点名称 | CD255 / TWEAK |
| 抗原物种 | Human |
| 抗原 | Human CD255-transfected 2PK-3 cells. |
| 偶联标记 | Un-conjugated |
| 別名 | APO3L; DR3LG; TWEAK; TNLG4A |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 纯化说明 | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein. |
| 缓冲液 | TBS |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O43508 Human Tumor necrosis factor ligand superfamily member 12 |
|---|---|
| 基因名称 | TNFSF12 |
| 全名 | TNF superfamily member 12 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] |
| 生物功能 | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. [UniProt] |
| 细胞定位 | Plasma membrane; Extracellular region or secreted. [UniProt] |
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