anti-CD255 / TWEAK antibody [CARL-1] (PE)

产品描述: PE-conjugated Mouse Monoclonal antibody [CARL-1] recognizes CD255 / TWEAK
反应物种: Hu
应用: FACS
特异性: The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
宿主: Mouse
克隆: Monoclonal
克隆号: CARL-1
同位型: IgG3, kappa
靶点名称: CD255 / TWEAK

CAT.NO. : ARG42385

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Size:

50 tests

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Product Details

概述

产品描述	PE-conjugated Mouse Monoclonal antibody [CARL-1] recognizes CD255 / TWEAK
反应物种	Hu
应用	FACS
特异性	The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
宿主	Mouse
克隆	Monoclonal
克隆号	CARL-1
同位型	IgG3, kappa
靶点名称	CD255 / TWEAK
抗原物种	Human
抗原	Human CD255-transfected 2PK-3 cells.
偶联标记	PE
別名	APO3L; DR3LG; TWEAK; TNLG4A

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8742 Human TNFSF12 Swiss-port # O43508 Human Tumor necrosis factor ligand superfamily member 12
基因名称	TNFSF12
全名	TNF superfamily member 12
背景介绍	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
生物功能	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. [UniProt]
细胞定位	Plasma membrane; Extracellular region or secreted. [UniProt]

检测图片 (1)

ARG42385 anti-CD255 / TWEAK antibody [CARL-1] (PE) FACS image
Flow Cytometry: Separation of CD255 transfected L5178Y cells (red-filled) from non-transfected L5178Y cells (black-dashed). Cells were stained with ARG42385 anti-CD255 / TWEAK antibody [CARL-1] (PE) (10 µl reagent / 10^6 cells in 100 µl of cell suspension).

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