anti-CD262 / TRAIL R2 antibody [DR5-01-1] (APC)
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Key features and details
- 产品描述:
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- 应用:
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- 靶点名称:
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Brand:
CAT.NO. : ARG42324
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Product Details
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [DR5-01-1] recognizes CD262 / TRAIL R2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily members that contain death domain for TRAIL (APO2L). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | DR5-01-1 |
| 同位型 | IgG1 |
| 靶点名称 | CD262 / TRAIL R2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein of Human IgG heavy chain and extracellular domain of CD262. |
| 偶联标记 | APC |
| 別名 | TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| 基因名称 | TNFRSF10B |
| 全名 | tumor necrosis factor receptor superfamily, member 10b |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] |
| 生物功能 | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 48 kDa |
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