anti-CD300a + CD300c antibody [MEM-260] (APC)

产品描述: APC-conjugated Mouse Monoclonal antibody [MEM-260] recognizes CD300a + CD300c
反应物种: Hu
应用: FACS
特异性: The antibody MEM-260 reacts with an extracellular epitope of CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-260
同位型: IgG1
靶点名称: CD300a + CD300c

CAT.NO. : ARG42422

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Size:

50 tests

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Product Details

概述

产品描述	APC-conjugated Mouse Monoclonal antibody [MEM-260] recognizes CD300a + CD300c
反应物种	Hu
应用	FACS
特异性	The antibody MEM-260 reacts with an extracellular epitope of CD300a, a 60 kDa leukocyte transmembrane glycoprotein expressed on human granulocytes, monocytes, neutrophils, NK cells, mast cells and dendritic cells, 25% of circulating T cells and 15% of circulating B cells.
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-260
同位型	IgG1
靶点名称	CD300a + CD300c
抗原物种	Human
抗原	HPB Human acute lymphoid leukemia cell line.
偶联标记	APC
別名	CMRF-35-H9; Inhibitory receptor protein 60; NK inhibitory receptor; CMRF35-H; CMRF35H9; CD antigen CD300a; IRC1/IRC2; IGSF12; CMRF35H; IRp60; IgSF12; CMRF35-like molecule 8; CMRF35-H9; CMRF-35H; CD300 antigen-like family member A; CLM-8; IRC1; IRC2; Immunoglobulin superfamily member 12

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 11314 Human CD300A Swiss-port # Q9UGN4 Human CMRF35-like molecule 8
基因名称	CD300A
全名	CD300a molecule
背景介绍	This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
生物功能	Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). [UniProt]
细胞定位	Cell membrane; Single-pass type I membrane protein. [UniProt]
预测分子量	33 kDa
翻译后修饰	Phosphorylated on tyrosine. N-glycosylated. [UniProt]

检测图片 (1)

ARG42422 anti-CD300a + CD300c antibody [MEM-260] (APC) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG42422 anti-CD300a + CD300c antibody [MEM-260] (APC).

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