anti-CD328 / Siglec 7 antibody [6-434] (PE)

产品描述: PE-conjugated Mouse Monoclonal antibody [6-434] recognizes CD328 / Siglec 7
反应物种: Hu
应用: FACS
特异性: The mouse monoclonal antibody 6-434 recognizes an extracellular epitope of CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
宿主: Mouse
克隆: Monoclonal
克隆号: 6-434
同位型: IgG1
靶点名称: CD328 / Siglec 7

CAT.NO. : ARG42278

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Size:

50 tests

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Product Details

概述

产品描述	PE-conjugated Mouse Monoclonal antibody [6-434] recognizes CD328 / Siglec 7
反应物种	Hu
应用	FACS
特异性	The mouse monoclonal antibody 6-434 recognizes an extracellular epitope of CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
宿主	Mouse
克隆	Monoclonal
克隆号	6-434
同位型	IgG1
靶点名称	CD328 / Siglec 7
抗原物种	Human
抗原	Human dendritic cells.
偶联标记	PE
別名	QA79 membrane protein; p75; CD antigen CD328; SIGLEC19P; Adhesion inhibitory receptor molecule 1; SIGLECP2; Sialic acid-binding Ig-like lectin 7; SIGLEC-7; p75/AIRM1; CDw328; Siglec-7; AIRM-1; CD328; AIRM1; D-siglec; QA79

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 27036 Human SIGLEC7 Swiss-port # Q9Y286 Human Sialic acid-binding Ig-like lectin 7
基因名称	SIGLEC7
全名	sialic acid binding Ig-like lectin 7
生物功能	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). [UniProt]
细胞定位	Membrane; Single-pass type I membrane protein. [UniProt]
预测分子量	51 kDa
翻译后修饰	Tyrosine phosphorylated. [UniProt]

检测图片 (3)

ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) at 10 µl / 100 µl of peripheral whole blood.
ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) at 10 µl / 100 µl of peripheral whole blood and anti-CD56 antibody [LT56] (APC) at 10 µl / 100 µl of peripheral whole blood.
ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) FACS image
Flow Cytometry: Separation of Human CD328 positive CD56 positive NK cells (red-filled) from CD328 negative CD56 negative lymphocytes (black-dashed). Human peripheral whole blood stained with ARG42278 anti-CD328 / Siglec 7 antibody [6-434] (PE) at 10 µl / 100 µl of peripheral whole blood.

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