anti-CD32B antibody [AT130-5R]

产品描述: Rat Monoclonal antibody [AT130-5R] recognizes CD32B.Rat anti Mouse CD32B, clone AT130-5R, recognizes mouse CD32B also known as FcRIIB. CD32B (FcRIIB) is a low affinity receptor for IgG1, IgG2a and IgG2b type antibodies. Unlike other FcRs, the intracellular domain of CD32 contains a inhibitory signalling motif (ITIM) that can antagonize signal transduction mediated through other activatory receptors. FcRIIB is expressed on all myeloid populations and on B-cells.
反应物种: Ms
应用: IHC-Fr
宿主: Rat
克隆: Monoclonal
克隆号: AT130-5R
同位型: IgG2b
靶点名称: CD32B
抗原物种: Mouse

CAT.NO. : ARG23573

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Size:

100 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Rat Monoclonal antibody [AT130-5R] recognizes CD32B. Rat anti Mouse CD32B, clone AT130-5R, recognizes mouse CD32B also known as FcRIIB. CD32B (FcRIIB) is a low affinity receptor for IgG1, IgG2a and IgG2b type antibodies. Unlike other FcRs, the intracellular domain of CD32 contains a inhibitory signalling motif (ITIM) that can antagonize signal transduction mediated through other activatory receptors. FcRIIB is expressed on all myeloid populations and on B-cells.
反应物种	Ms
应用	IHC-Fr
宿主	Rat
克隆	Monoclonal
克隆号	AT130-5R
同位型	IgG2b
靶点名称	CD32B
抗原物种	Mouse
抗原	Mouse CD32-Rat CD4 fusion protein.
偶联标记	Un-conjugated
別名	Fc-gamma-RIIc; Fc-gamma RII-c; CD32; CD antigen CD32; CD32B; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-c; FCG2; IGFR2; FcRII-c; FCGR2; CDw32

应用说明

应用建议

应用	推荐稀释比
IHC-Fr	1:200

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	TRIS buffered saline and 0.09% Sodium azide.
抗菌剂	0.09% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 14130 Mouse FCGR2B Swiss-port # P08101 Mouse Low affinity immunoglobulin gamma Fc region receptor II
基因名称	FCGR2B
全名	Fc fragment of IgG, low affinity IIb, receptor (CD32)
背景介绍	The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
生物功能	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. [UniProt]
预测分子量	36 kDa
翻译后修饰	Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. [UniProt]

检测图片 (1)

ARG23573 anti-CD32B antibody [AT130-5R] IHC-Fr image
Immunohistochemistry: Acetone-fixed frozen sections of BALB/c WT and CD32B -/- Mouse spleen and liver (10 µm) stained with ARG23573 anti-CD32B antibody [AT130-5R] at 5 µg/ml followed by an anti-Rat IgG HRP polymer and counterstained with Haematoxylin.

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