anti-CD35 / CR1 antibody [E11] (PE)
![anti-CD35 / CR1 antibody [E11] (PE)](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
- 反应物种:
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- 克隆:
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- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG54242
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [E11] recognizes CD35 / CR1 |
|---|---|
| 反应物种 | Hu, Bb, Chimp, R. Mk |
| 应用 | ELISA, FACS, IHC-Fr, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | E11 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD35 / CR1 |
| 抗原物种 | Human |
| 抗原 | Acute monocytic leukemia cells and normal blood monocytes |
| 偶联标记 | PE |
| 別名 | C3b/C4b receptor; C4BR; CD antigen CD35; KN; CD35; C3BR; Complement receptor type 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and Sucrose. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | Sucrose |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CR1 |
| 全名 | complement component (3b/4b) receptor 1 (Knops blood group) |
| 背景介绍 | CD35 (complement receptor 1, CR1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production. |
| 生物功能 | Mediates cellular binding of particles and immune complexes that have activated complement. [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 224 kDa |
参考文献
克隆号文献
Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.
ELISA /
Effect of B-cell depletion on coreceptor switching in R5 simian-human immunodeficiency virus infection of rhesus macaques.
IHC / Human
Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum.
ELISA / Human
Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1).
Monoclonal antibodies differentiating between monocytic and nonmonocytic variants of AML.
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