anti-CD41 antibody [MEM-06] (PerCP)

产品描述: PerCP-conjugated Mouse Monoclonal antibody [MEM-06] recognizes CD41
反应物种: Hu
应用: FACS
特异性: The antibody MEM-06 reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-06
同位型: IgG1
靶点名称: CD41

CAT.NO. : ARG42249

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Size:

50 tests

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Product Details

概述

产品描述	PerCP-conjugated Mouse Monoclonal antibody [MEM-06] recognizes CD41
反应物种	Hu
应用	FACS
特异性	The antibody MEM-06 reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-06
同位型	IgG1
靶点名称	CD41
抗原物种	Human
抗原	Leukocytes of a patient suffering from LGL-type leukaemia.
偶联标记	PerCP
別名	GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B

应用说明

应用建议

应用	推荐稀释比
FACS	10 µl / 100 µl of whole blood or 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified
缓冲液	PBS and 15 mM Sodium azide.
抗菌剂	15 mM Sodium azide
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3674 Human ITGA2B Swiss-port # P08514 Human Integrin alpha-IIb
基因名称	ITGA2B
全名	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
背景介绍	This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
生物功能	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt]
细胞定位	Membrane; Single-pass type I membrane protein. [UniProt]
预测分子量	113 kDa

检测图片 (1)

ARG42249 anti-CD41 antibody [MEM-06] (PerCP) FACS image
Flow Cytometry: Human platelets stained with ARG42249 anti-CD41 antibody [MEM-06] (PerCP).

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