anti-CD41 antibody [MWReg30] (low endotoxin)
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CAT.NO. : ARG65621
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Product Details
概述
| 产品描述 | Low endotoxin Rat Monoclonal antibody [MWReg30] recognizes CD41 (low endotoxin) |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA, FACS, FuncSt, IHC-Fr, IHC-P, IP |
| 特异性 | This antibody recognizes CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | MWReg30 |
| 同位型 | IgG1 |
| 靶点名称 | CD41 |
| 抗原物种 | Mouse |
| 抗原 | Murine platelets |
| 偶联标记 | Un-conjugated |
| 別名 | GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B |
应用说明
| 应用建议 |
| ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Functional application: Platelet depletion. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 纯化说明 | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Itga2b |
| 全名 | integrin alpha 2b |
| 背景介绍 | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 113 kDa |
参考文献
克隆号文献
Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche.
Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, platelet factor-4.
IHC-P / Mouse
ERG is a megakaryocytic oncogene.
FACS / Human
Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.
Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.
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