anti-CD41 antibody [Q90]

Key features and details

  • 产品描述: Mouse Monoclonal antibody[Q90] recognizes CD41
  • 反应物种: Hu
  • 预测物种: Ms
  • 应用: IHC-P
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: Q90
  • 同位型: IgG
  • 靶点名称: CD41
  • Brand:
CAT.NO. : ARG66911
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Product Details
概述
产品描述Mouse Monoclonal antibody[Q90] recognizes CD41
反应物种Hu
预测物种Ms
应用IHC-P
宿主Mouse
克隆Monoclonal
克隆号Q90
同位型IgG
靶点名称CD41
抗原物种Human
抗原Synthetic peptide corresponding to Human CD41.
偶联标记Un-conjugated
Protein Full nameIntegrin alpha-IIb
別名GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.4), 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol and 0.5% BSA
浓度Batch dependent
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 3674 Human ITGA2B

Swiss-port # P08514 Human Integrin alpha-IIb

基因名称ITGA2B
全名integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
背景介绍ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
生物功能Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt]
细胞定位Membrane; Single-pass type I membrane protein. [UniProt]
预测分子量113 kDa
翻译后修饰Cleavage on pair of basic residues; Disulfide bond; Glycoprotein; Pyrrolidone carboxylic acid
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