anti-CD41 + CD61 antibody [CO.35E4]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [CO.35E4] recognizes CD41 + CD61This antibody recognizes ruminant CD41/CD61, also known as GpIIb/IIIa. CD41/CD61 is a calcium-complex dependent heterodimer and is expressed almost exclusively on platelets and on their precursors, the megakaryocytes. This complex is an activation-dependent receptor for RGD (Arg-Gly-Asp)-containing glycoproteins such as fibrinogen, fibronectin, von Willebrand factor, thrombospondin and vitronectin. It plays a central role in platelet aggregation and haemostasis.
  • 反应物种: Bov, Cat, Dog, Goat, Hrs, Rb, Sheep
  • 应用: ELISA, FACS, IP
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: CO.35E4
  • 同位型: IgG1
  • 靶点名称: CD41 + CD61
  • 抗原物种: Sheep
  • Brand:
CAT.NO. : ARG22713
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Product Details
概述
产品描述Mouse Monoclonal antibody [CO.35E4] recognizes CD41 + CD61
This antibody recognizes ruminant CD41/CD61, also known as GpIIb/IIIa. CD41/CD61 is a calcium-complex dependent heterodimer and is expressed almost exclusively on platelets and on their precursors, the megakaryocytes. This complex is an activation-dependent receptor for RGD (Arg-Gly-Asp)-containing glycoproteins such as fibrinogen, fibronectin, von Willebrand factor, thrombospondin and vitronectin. It plays a central role in platelet aggregation and haemostasis.
反应物种Bov, Cat, Dog, Goat, Hrs, Rb, Sheep
应用ELISA, FACS, IP
宿主Mouse
克隆Monoclonal
克隆号CO.35E4
同位型IgG1
靶点名称CD41 + CD61
抗原物种Sheep
抗原Sheep leucocytes
偶联标记Un-conjugated
別名GTA; GT; GPalpha IIb; PPP1R93; CD41; BDPLT2; BDPLT16; GP2B; Integrin alpha-IIb; GPIIb; Platelet membrane glycoprotein IIb; HPA3; CD antigen CD41; CD41B
应用说明
应用建议
应用推荐稀释比
ELISAAssay-dependent
FACS1:50 - 1:200
IPAssay-dependent
应用说明FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% Sodium azide.
抗菌剂0.09% Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
基因名称ITGA2B
全名integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
背景介绍ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
生物功能Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. [UniProt]
预测分子量113 kDa
检测图片 (1)
  • ARG22713 anti-CD41 + CD61 antibody [CO.35E4] FACS image

    Flow Cytometry: Sheep peripheral blood platelets stained with ARG22713 anti-CD41 + CD61 antibody [CO.35E4].

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