anti-CD41-CD61 Complex antibody [IVA30]
![anti-CD41-CD61 Complex antibody [IVA30]](/upload/image/products/ARG62843_IF_1_210_205.jpg)
![anti-CD41-CD61 Complex antibody [IVA30]](/upload/image/products/ARG62843_IF_1.jpg)
Key features and details
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- 特异性:
- 宿主:
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- 靶点名称:
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CAT.NO. : ARG62843
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [IVA30] recognizes CD41-CD61 Complex |
|---|---|
| 反应物种 | Bov |
| 应用 | ELISA, FACS, ICC/IF, IP |
| 特异性 | The clone IVA30 reacts with CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | IVA30 |
| 同位型 | IgG2 |
| 靶点名称 | CD41-CD61 Complex |
| 抗原物种 | Bovine |
| 抗原 | Bovine trombocytes. |
| 偶联标记 | Un-conjugated |
| 別名 | GT; CD antigen CD61; CD61; BDPLT2; GPIIIa; BDPLT16; GP3A; Platelet membrane glycoprotein IIIa; Integrin beta-3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 背景介绍 | CD41 is a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD61 non-covalently associates with CD41. |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 87 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. |
检测图片 (1)
ARG62843 anti-CD41-CD61 Complex antibody [IVA30] ICC/IF image
Immunofluorescence: Acetone / methanol-fixed Bovine peripheral blood (thrombocyte-enriched suspension) stained with ARG62843 anti-CD41-CD61 Complex antibody [IVA30] (green signal at thrombocytes), DAPI (blue) for nuclear staining.
参考文献
克隆号文献
Nomenclature and characterization of leukocyte differentiation antigens in ruminants.
Immunohistochemical reactivity of anti-platelet monoclonal antibodies.
Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies.
Ruminant cluster CD41/CD61.
Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995.
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