anti-CD43 antibody [MEM-59] (PE)
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CAT.NO. : ARG53849
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [MEM-59] recognizes CD43 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone MEM-59 recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocytes; it is negative on resting B lymphocytes and erythrocytes. HLDA IV; WS Code NL 604 HLDA V; WS Code AS S290 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-59 |
| 同位型 | IgG1 |
| 靶点名称 | CD43 |
| 抗原物种 | Human |
| 抗原 | Human T lymphocytes. |
| 偶联标记 | PE |
| 別名 | CD antigen CD43; B-cell differentiation antigen LP-3; Sialophorin; Cd43; Galgp; A630014B01Rik; Ly-48; Lymphocyte antigen 48; Ly48; Leukocyte sialoglycoprotein; Leukosialin |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SPN |
| 全名 | sialophorin |
| 背景介绍 | CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions. |
| 生物功能 | One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). [UniProt] |
| 研究领域 | Developmental Biology antibody; Immune System antibody |
| 预测分子量 | 40 kDa |
检测图片 (1)
ARG53849 anti-CD43 antibody [MEM-59] (PE) FACS image
Flow Cytometry: Human peripheral blood stained with ARG53849 anti-CD43 antibody [MEM-59] (PE).
参考文献
克隆号文献
CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models.
FACS / Mouse
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
WB / Mouse
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.
MEM-59 monoclonal antibody detects a CD43 epitope involved in lymphocyte activation.
CD59 molecule: a second ligand for CD2 in T cell adhesion.
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