anti-CD48 antibody [MEM-102]
![anti-CD48 antibody [MEM-102]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG62874
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [MEM-102] recognizes CD48 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS, IHC-P, IP, WB |
| 特异性 | The clone MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells; it is negative on granulocytes, platelets and erythrocytes. HLDA V; WS Code AS S014 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-102 |
| 同位型 | IgG1 |
| 靶点名称 | CD48 |
| 抗原物种 | Human |
| 抗原 | Raji human Burkitt's lymphoma cell line |
| 偶联标记 | Un-conjugated |
| 別名 | Leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen; BCM1 surface antigen; CD antigen CD48; TCT.1; BLAST1; BCM1; MEM-102; mCD48; Signaling lymphocytic activation molecule 2; BLAST; hCD48; SLAMF2; SLAM family member 2 |
应用说明
| 应用建议 |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD48 |
| 全名 | CD48 molecule |
| 背景介绍 | CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of their family, thus mediate homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases. |
| 生物功能 | Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 28 kDa |
参考文献
克隆号文献
Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement.
Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol.
The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1.
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