anti-CD51 / Integrin alpha V antibody [13C2]
![anti-CD51 / Integrin alpha V antibody [13C2]](/upload/image/products/ARG21381_FACS_1_190906_210_205.jpg)
![anti-CD51 / Integrin alpha V antibody [13C2]](/upload/image/products/ARG21381_FACS_1_190906.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG21381
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [13C2] recognizes CD51 / Integrin alpha V |
|---|---|
| 反应物种 | Hu, AGMK, Bov, Rb |
| 应用 | BL, Depletion, ELISA, FACS, ICC/IF, IHC-Fr, IP, Puri |
| 特异性 | Human/African Green Monkey/Rabbit/Bovine CD51. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 13C2 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD51 / Integrin alpha V |
| 抗原物种 | Human |
| 抗原 | Cell suspension containing osteoclasts from osteoclastomas |
| 偶联标记 | Un-conjugated |
| 別名 | CD51; VNRA; CD antigen CD51; VTNR; Vitronectin receptor subunit alpha; Integrin alpha-V; MSK8 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGAV |
| 全名 | integrin, alpha V |
| 背景介绍 | This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015] |
| 生物功能 | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt] |
| 预测分子量 | 116 kDa |
检测图片 (1)
ARG21381 anti-CD51 / Integrin alpha V antibody [13C2] FACS image
Flow Cytometry: Human HPV-16 E6/E7 transformed cell line HS-5 was stained with ARG21381 anti-CD51 / Integrin alpha V antibody [13C2] followed by ARG21565 Goat anti-Mouse IgG1 antibody (PE) (pre-adsorbed).
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