anti-CD55 antibody [MEM-118] (Biotin)

产品描述: Biotin-conjugated Mouse Monoclonal antibody [MEM-118] recognizes CD55
反应物种: Hu, NHuPrm
应用: FACS
特异性: The clone MEM-118 recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.HLDA V; WS Code AS S016
宿主: Mouse
克隆: Monoclonal
克隆号: MEM-118
同位型: IgM
靶点名称: CD55

CAT.NO. : ARG62890

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Size:

100 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Biotin-conjugated Mouse Monoclonal antibody [MEM-118] recognizes CD55
反应物种	Hu, NHuPrm
应用	FACS
特异性	The clone MEM-118 recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells. HLDA V; WS Code AS S016
宿主	Mouse
克隆	Monoclonal
克隆号	MEM-118
同位型	IgM
靶点名称	CD55
抗原物种	Human
抗原	HPB-ALL human T cell line
偶联标记	Biotin
別名	DAF; CD antigen CD55; CROM; Complement decay-accelerating factor; CR; TC

应用说明

应用建议

应用	推荐稀释比
FACS	5 - 8 µg/ml

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化说明	The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
缓冲液	TBS (pH 8.0) and 15 mM Sodium azide
抗菌剂	15 mM Sodium azide
浓度	1 mg/ml
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 1604 Human CD55 Swiss-port # P08174 Human Complement decay-accelerating factor
基因名称	CD55
全名	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
背景介绍	CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
生物功能	This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. [UniProt]
研究领域	Immune System antibody
预测分子量	41 kDa
翻译后修饰	The Ser/Thr-rich domain is heavily O-glycosylated.

检测图片 (1)

ARG62890 anti-CD55 antibody [MEM-118] (Biotin) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG62890 anti-CD55 antibody [MEM-118] (Biotin), followed by Streptavidin (APC).

参考文献

克隆号文献

Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection.

ICC/IF / Human

Lee MS et al.
PLoS Pathog., (2014)