anti-CD62L / L-Selectin antibody [IVA94]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [IVA94] recognizes CD62L / L-Selectin
  • 反应物种: Bov
  • 应用: FACS, ICC/IF, IP
  • 特异性: The clone IVA94 reacts with CD62L antigen (bovine). CD62L (L-selectin) is a 74-95 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: IVA94
  • 同位型: IgG1
  • 靶点名称: CD62L / L-Selectin
  • Brand:
CAT.NO. : ARG62908
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Product Details
概述
产品描述Mouse Monoclonal antibody [IVA94] recognizes CD62L / L-Selectin
反应物种Bov
应用FACS, ICC/IF, IP
特异性The clone IVA94 reacts with CD62L antigen (bovine). CD62L (L-selectin) is a 74-95 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells.
宿主Mouse
克隆Monoclonal
克隆号IVA94
同位型IgG1
靶点名称CD62L / L-Selectin
抗原Bovine leukocytes.
偶联标记Un-conjugated
別名Leukocyte surface antigen Leu-8; Leukocyte adhesion molecule 1; CD antigen CD62L; PLNHR; LSEL; CD62L; Leukocyte-endothelial cell adhesion molecule 1; L-selectin; LAM1; LNHR; TQ1; CD62 antigen-like family member L; gp90-MEL; Lymph node homing receptor; LYAM1; LECAM1; LEU8; LAM-1
应用说明
应用建议
应用推荐稀释比
FACS1 - 4 µg/ml
ICC/IFAssay-dependent
IPAssay-dependent
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purified from ascites by protein-A affinity chromatography.
纯度> 95% (by SDS-PAGE)
缓冲液PBS (pH 7.4) and 15 mM Sodium azide
抗菌剂15 mM Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 281485 Bovine SELL

Swiss-port # P98131 Bovine L-selectin

基因名称SELL
全名selectin L
背景介绍This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
生物功能Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity). [UniProt]
研究领域Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody
预测分子量42 kDa
检测图片 (3)
  • ARG62908 anti-CD62L / L-Selectin antibody [IVA94] ICC/IF image

    Immunofluorescence: Acetone / methanol-fixed Bovine peripheral blood (lymphocyte-enriched suspension) stained with ARG62908 anti-CD62L / L-Selectin antibody [IVA94] (green), DAPI (blue) for nuclear staining.

  • ARG62908 anti-CD62L / L-Selectin antibody [IVA94] FACS image

    Flow Cytometry: Separation of bovine CD62L positive lymphocytes (red-filled) from CD62L negative lymphocytes (black-dashed). Bovine peripheral whole blood stained with ARG62908 anti-CD62L / L-Selectin antibody [IVA94] at 1 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody.

  • ARG62908 anti-CD62L / L-Selectin antibody [IVA94] FACS image

    Flow Cytometry: Bovine peripheral whole blood stained with ARG62908 anti-CD62L / L-Selectin antibody [IVA94] at 1 µg/ml dilution, followed by APC-conjugated Goat anti-Mouse antibody.

参考文献

克隆号文献

Nomenclature and characterization of leukocyte differentiation antigens in ruminants.

Naessens J et al.
Immunol Today.,  (1997)

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Biochemical analysis of preliminary clusters in the non-lineage panel.

Naessens J et al.
Vet Immunol Immunopathol.,  (1996)

publication_link

 

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Ruminant cluster CD62L.

Howard CJ et al.
Vet Immunol Immunopathol.,  (1996)

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Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995.

[No authors listed] et al.
Vet Immunol Immunopathol.,  (1996)

publication_link

 

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