anti-CD62L / L-Selectin antibody [MEL-14] (low endotoxin)
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CAT.NO. : ARG65485
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Product Details
概述
| 产品描述 | Azide free and low endotoxin Rat Monoclonal antibody [MEL-14] recognizes CD62L / L-Selectin |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS, FuncSt, ICC/IF, IHC-Fr, IHC-P, IP |
| 特异性 | The clone MEL-14 reacts with mouse CD62L (L-selectin), a 75 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells._x000D_ |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | MEL-14 |
| 同位型 | IgG2a |
| 靶点名称 | CD62L / L-Selectin |
| 抗原物种 | Mouse |
| 抗原 | C3H/eb mouse B cell lymphoma 38C-13_x000D_ |
| 偶联标记 | Un-conjugated |
| 別名 | Leukocyte surface antigen Leu-8; Leukocyte adhesion molecule 1; CD antigen CD62L; PLNHR; LSEL; CD62L; Leukocyte-endothelial cell adhesion molecule 1; L-selectin; LAM1; LNHR; TQ1; CD62 antigen-like family member L; gp90-MEL; Lymph node homing receptor; LYAM1; LECAM1; LEU8; LAM-1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Functional studies: Blocking of cell adhesion. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 纯化说明 | 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Sell |
| 全名 | selectin, lymphocyte |
| 背景介绍 | CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). _x000D_ |
| 生物功能 | Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity). [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 42 kDa |
参考文献
克隆号文献
Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity.
ICC/IF /
Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization.
IL-10 restricts memory T cell inflation during cytomegalovirus infection.
FACS / Mouse
TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infection.
FACS / Mouse
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