anti-CD66e / CEA antibody [CB30]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [CB30] recognizes CD66e / CEA
  • 反应物种: Hu
  • 应用: FACS, IHC-Fr, IHC-P, IP
  • 特异性: The clone CB30 recognizes CD66e (CEA; 180-200 kDa), a cell surface bound carcinoembryonic antigen mainly expressed on epithelial cells.
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: CB30
  • 同位型: IgG1
  • 靶点名称: CD66e / CEA
  • Brand:
CAT.NO. : ARG62915
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Product Details
概述
产品描述Mouse Monoclonal antibody [CB30] recognizes CD66e / CEA
反应物种Hu
应用FACS, IHC-Fr, IHC-P, IP
特异性The clone CB30 recognizes CD66e (CEA; 180-200 kDa), a cell surface bound carcinoembryonic antigen mainly expressed on epithelial cells.
宿主Mouse
克隆Monoclonal
克隆号CB30
同位型IgG1
靶点名称CD66e / CEA
抗原物种Human
抗原Human carcinoembryonic antigen (CEA; CEACAM5)
偶联标记Un-conjugated
別名Carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; CD antigen CD66e; Carcinoembryonic antigen; Meconium antigen 100
应用说明
应用建议
应用推荐稀释比
FACSAssay-dependent
IHC-FrAssay-dependent
IHC-P1:100
IPAssay-dependent
应用说明IHC-P: Staining technique: Standard ABC technique (DAB+). Pretreatment: 0.1% pepsin in 0.1M HCl for 30 min at RT.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照IHC-P: Adenocarcinoma of colon
属性
形式Liquid
纯化Purified from hybridoma culture supernatant by protein-A affinity chromatography.
纯度> 95% (by SDS-PAGE)
缓冲液PBS (pH 7.4) and 15 mM Sodium azide
抗菌剂15 mM Sodium azide
浓度1 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1048 Human CEACAM5

Swiss-port # P06731 Human Carcinoembryonic antigen-related cell adhesion molecule 5

基因名称CEACAM5
全名carcinoembryonic antigen-related cell adhesion molecule 5
背景介绍The CD66e (CEA; 180-200 kDa) is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion.
Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas - potential target of tumor imaging and drug targeting._x000D_
生物功能Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. [UniProt]
研究领域Cancer antibody; Developmental Biology antibody; Controls and Markers antibody; Microbiology and Infectious Disease antibody
预测分子量77 kDa
翻译后修饰Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
检测图片 (2)
  • ARG62915 anti-CD66e / CEA antibody [CB30] IHC-P image

    Immunohistochemistry: Colorectal carcinoma (paraffin-embedded sections) stained with ARG62915 anti-CD66e / CEA antibody [CB30].

  • ARG62915 anti-CD66e / CEA antibody [CB30] IHC-P image

    Immunohistochemistry: Colorectal carcinoma (paraffin-embedded sections) stained with ARG62915 anti-CD66e / CEA antibody [CB30].

参考文献

克隆号文献

Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays.

Ashley N et al.
J Pathol.,  (2014)

publication_link

 

hr_line

Establishment of human ultra-low passage colorectal cancer cell lines using spheroids from fresh surgical specimens suitable for in vitro and in vivo studies.

FACS / 

Ray S et al.
J Cancer.,  (2012)

publication_link

 

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