anti-CD70 antibody [Ki-24] (PE)
![anti-CD70 antibody [Ki-24] (PE)](/upload/image/products/ARG42337_FACS_1_210_205.jpg)
![anti-CD70 antibody [Ki-24] (PE)](/upload/image/products/ARG42337_FACS_1.jpg)
Key features and details
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CAT.NO. : ARG42337
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [Ki-24] recognizes CD70 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | Ki-24 |
| 同位型 | IgG3, kappa |
| 靶点名称 | CD70 |
| 抗原物种 | Human |
| 抗原 | Human CD70. |
| 偶联标记 | PE |
| 別名 | CD27 ligand; CD70 antigen; Tumor necrosis factor ligand superfamily member 7; CD antigen CD70; CD27L; CD27-L; TNFSF7; CD27LG |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD70 |
| 全名 | CD70 molecule |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. [UniProt] |
| 细胞定位 | Membrane; Single-pass type II membrane protein. [UniProt] |
| 预测分子量 | 21 kDa |
检测图片 (1)
ARG42337 anti-CD70 antibody [Ki-24] (PE) FACS image
Flow Cytometry: HUT-78 cells (red-filled) and K562 cells (black-dashed, negative sample) stained with ARG42337 anti-CD70 antibody [Ki-24] (PE).
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