anti-CD72 antibody [3F3]

产品描述: Mouse Monoclonal antibody [3F3] recognizes CD72
反应物种: Hu
应用: FACS, IP
特异性: The clone 3F3 reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells; it is also present on follicular dendritic cells.HLDA V; WS Code B CD72.5 HLDA VI; WS Code B CD72.1 HLDA VI; WS Code 6 BP 84
宿主: Mouse
克隆: Monoclonal
克隆号: 3F3
同位型: IgG2b
靶点名称: CD72

CAT.NO. : ARG62925

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Size:

100 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [3F3] recognizes CD72
反应物种	Hu
应用	FACS, IP
特异性	The clone 3F3 reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells; it is also present on follicular dendritic cells. HLDA V; WS Code B CD72.5 HLDA VI; WS Code B CD72.1 HLDA VI; WS Code 6 BP 84
宿主	Mouse
克隆	Monoclonal
克隆号	3F3
同位型	IgG2b
靶点名称	CD72
抗原物种	Human
抗原	Normal human lymphocytes from a lymph node.
偶联标记	Un-conjugated
別名	CD antigen CD72; LYB2; B-cell differentiation antigen CD72; Lyb-2; CD72b

应用说明

应用建议

应用	推荐稀释比
FACS	1 µg/ml
IP	Assay-dependent

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purified from ascites by precipitation methods and ion exchange chromatography.
纯度	> 95% (by SDS-PAGE)
缓冲液	PBS (pH 7.4) and 15 mM Sodium azide
抗菌剂	15 mM Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 971 Human CD72 Swiss-port # P21854 Human B-cell differentiation antigen CD72
基因名称	CD72
全名	CD72 molecule
背景介绍	CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
生物功能	Plays a role in B-cell proliferation and differentiation. [UniProt]
研究领域	Developmental Biology antibody; Immune System antibody
预测分子量	40 kDa
翻译后修饰	Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).

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