anti-CD74 antibody [LN2] (FITC)

CAT.NO. : ARG55521

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Size:

500 μl

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	FITC-conjugated Mouse Monoclonal antibody [LN2] recognizes CD74
反应物种	Hu
不反应物种	Rat
应用	FACS, ICC/IF, IHC-Fr, IHC-P, WB
宿主	Mouse
克隆	Monoclonal
克隆号	LN2
同位型	IgG1, kappa
靶点名称	CD74
抗原物种	Human
抗原	SU-DHL-4 lymphoma cells.
偶联标记	FITC
別名	DHLAG; Ii; CD antigen CD74; II; HLA-DR antigens-associated invariant chain; Ia-GAMMA; Ia antigen-associated invariant chain; HLA class II histocompatibility antigen gamma chain; p33; HLADG

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

Human Raji cells, lymph node, tonsil

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS (pH 7.4), 0.05% Sodium azide and 1% BSA
抗菌剂	0.05% Sodium azide
稳定剂	1% BSA
浓度	0.2 mg/ml
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 972 Human CD74 Swiss-port # P04233 Human HLA class II histocompatibility antigen gamma chain
基因名称	CD74
全名	CD74 molecule, major histocompatibility complex, class II invariant chain
背景介绍	The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
生物功能	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [UniProt]
细胞定位	Cell membrane
研究领域	Immune System antibody
预测分子量	34 kDa
翻译后修饰	N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

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