anti-CD79b antibody [CB3-1] (FITC)
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Key features and details
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- 靶点名称:
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CAT.NO. : ARG21401
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Product Details
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [CB3-1] recognizes CD79b |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 特异性 | Human CD79b. The clone CB3-1 reacts with the β chain of CD79. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CB3-1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD79b |
| 抗原物种 | Human |
| 抗原 | Ramos B cells |
| 偶联标记 | FITC |
| 別名 | B29; B-cell-specific glycoprotein B29; Ig-beta; B-cell antigen receptor complex-associated protein beta chain; Immunoglobulin-associated B29 protein; AGM6; IGB; CD antigen CD79b |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 0.1% Sodium azide. |
| 抗菌剂 | 0.1% Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P40259 Human B-cell antigen receptor complex-associated protein beta chain |
|---|---|
| 基因名称 | CD79B |
| 全名 | CD79b molecule, immunoglobulin-associated beta |
| 背景介绍 | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| 生物功能 | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt] |
| 预测分子量 | 26 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
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