anti-CDKN1C / p57 Kip2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG54738
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes CDKN1C / p57 Kip2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 522CT9.5.1 |
| 同位型 | IgM |
| 靶点名称 | CDKN1C / p57 Kip2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 34-64 of Human CDKN1C (NP_000067.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HL-60 |
属性
| 纯化 | Affinity purification with immunogen. |
|---|---|
| 缓冲液 | Crude ascites and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C |
|---|---|
| 基因名称 | CDKN1C |
| 全名 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| 背景介绍 | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| 生物功能 | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| 细胞定位 | Nucleus. |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| 预测分子量 | 32 kDa |
检测图片 (1)
ARG54738 anti-CDKN1C / p57 Kip2 antibody WB image
Western blot: 35 µg of HL-60 cell lysate stained with ARG54738 anti-CDKN1C / p57 Kip2 antibody.
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