anti-CEMIP antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59980
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CEMIP |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CEMIP |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 180-420 of Human CEMIP (NP_061159.1). |
| 偶联标记 | Un-conjugated |
| 別名 | CCSP1; Cell migration-inducing and hyaluronan-binding protein; EC 3.2.1.35; KIAA1199; TMEM2L |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse brain and U87 | ||||
| 实际分子量 | 180 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q8BI06 Mouse Cell migration-inducing and hyaluronan-binding protein Swiss-port # Q8WUJ3 Human Cell migration-inducing and hyaluronan-binding protein |
|---|---|
| 基因名称 | CEMIP |
| 全名 | cell migration inducing protein, hyaluronan binding |
| 生物功能 | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas. [UniProt] |
| 预测分子量 | 153 kDa |
| 翻译后修饰 | N-glycosylated; glycosylation is not necessary for HA-binding. [UniProt] |
检测图片 (1)
ARG59980 anti-CEMIP antibody WB image
Western blot: 25 µg of Mouse brain and U87 cell lysates stained with ARG59980 anti-CEMIP antibody at 1:3000 dilution.
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