anti-CHRM2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG55086
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody recognizes CHRM2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1424CT461.78.60 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CHRM2 |
| 抗原物种 | Human |
| 抗原 | Human CHRM2 Recombinant protein. |
| 偶联标记 | Un-conjugated |
| 別名 | Muscarinic acetylcholine receptor M2; HM2 |
应用说明
| 应用建议 |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | SH-SY5Y |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P08172 Human Muscarinic acetylcholine receptor M2 Swiss-port # Q9ERZ4 Mouse Muscarinic acetylcholine receptor M2 |
|---|---|
| 基因名称 | CHRM2 |
| 全名 | cholinergic receptor, muscarinic 2 |
| 背景介绍 | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization. |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Phosphorylated in response to agonist treatment. |
检测图片 (3)
ARG55086 anti-CHRM2 antibody ICC/IF image
Immunofluorescence: SH-SY5Y cells stained with ARG55086 anti-CHRM2 antibody (green) at 1:25 dilution. DAPI (blue) for nuclear staining.
ARG55086 anti-CHRM2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human heart tissue stained with ARG55086 anti-CHRM2 antibody at 1:25 dilution.
ARG55086 anti-CHRM2 antibody WB image
Western blot: 20 µg of SH-SY5Y cell lysate stained with ARG55086 anti-CHRM2 antibody at 1:500 dilution.
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